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Pharmacology and Toxicology
| Pharmacology and Toxicology 206a/b, Introductory Pharmacology and Therapeutics | |
| | Description: A course for students in the BSc in Nursing and other Health Sciences programs as well as students in BMSc and BSc programs, to provide a basic understanding of the fundamentals of drug action and the mechanisms of action and therapeutic use of the important classes of drugs. | | Pre- or Corequisite(s): Biochemistry 280a and Chemistry 213a/b or registration in the BSc in Nursing or the Health Information Management program in the Faculty of Health Sciences. | | 3 lecture hours, 1 tutorial hour (optional), 0.5 course. | | back to top |
| Pharmacology and Toxicology 355a/b, Principles of Drug Action | |
| | Description: This course will examine how drugs reach their intended targets, how they act and how their activities are terminated. Established drugs and novel therapeutic agents will be used as examples. Focus will be placed on interaction of drugs with specific receptors. | | Antirequisite(s): The former Pharmacology and Toxicology 357 | | Prerequisite(s): Biochemistry 280a or the permission of the Department. Biology 282b and Chemistry 223b are highly recommended. | | 2 lecture hours, 1 tutorial hour, 0.5 course. | | back to top |
| Pharmacology and Toxicology 356a/b, Introductory Toxicology | |
| | Description: Fundamentals of how chemicals produce toxicity in biological systems with application of underlying principles in environmental control and chemical poisoning. Included are aspects of dose-response relationship; physiological and biochemical processes involved in handling of toxicants following exposure; mechanisms of toxic action and their modification by chemical, environmental and biological factors. | | Antirequisite(s): The former Pharmacology and Toxicology 357 | | Prerequisite(s): Biochemistry 280a; Chemistry 213a/b or Chemistry 226a/b, or the permission of the Department. | | 2 lecture hours, 1 tutorial hour, 0.5 course. | | back to top |
| Pharmacology and Toxicology 358y, Pharmacology and Toxicology Laboratory | |
| | Description: A series of laboratory exercises, tutorials and presentations which introduce students to some of the basic approaches used in Pharmacology and Toxicology. | | Antirequisite(s): The former Pharmacology and Toxicology 357 | | Prerequisite(s): Biochemistry 280a and Chemistry 213a/b, or permission of the Department. A minimum average of 75% in the previous year is required. | | Corequisite(s): Pharmacology and Toxicology 355a/b or 356a/b | | Enrolment limited.
| | 3 laboratory hours (3 laboratory hours every other week and up to 3 tutorial hours, at the instructor's discretion, in alternate weeks). 0.5 course | | back to top |
| Pharmacology and Toxicology 432a/b, Cardiovascular Pharmacology | |
| | Description: Basic principles of cardiovascular pharmacology with particular emphasis on cellular mechanisms of drug action and mechanisms of therapeutic efficacy in disease states. | | Prerequisite(s): Pharmacology and Toxicology 355a/b and 358y, or the former Pharmacology and Toxicology 357, or Physiology 312, or the former Physiology 310; or Pharmacology 355a/b and registration in Year 4 of a module in Pathology and Toxicology, or permission of the Department. | | 2 lecture hours, 0.5 course. | | back to top |
| Pharmacology and Toxicology 436a/b, Mechanisms of Cancer Chemotherapy | |
| | Description: This course is designed to give students a basic understanding of the molecular pharmacology and therapeutic properties of anticancer agents. The focus is on molecular mechanisms of cancer chemotherapy, and will include drug resistance and the roles of receptor kinases and G protein-coupled receptors in existing and novel cancer therapies. | | Prerequisite(s): Pharmacology and Toxicology 355a/b, 356a/b and 358y (or the former Pharmacology and Toxicology 357); or Pharmacology and Toxicology 355a/b and registration in Year 4 of a module in Pathology and Toxicology, or permission from the Department. | | 2 lecture hours, 0.5 course. | | back to top |
| Pharmacology and Toxicology 438a/b, Neuropharmacology | |
| | Description: This course will focus on the cellular and molecular mechanisms underlying the actions of drugs on the central and peripheral nervous systems. The focus will be on recent developments in the field of neuroscience and their impact on our understanding of the actions, and development of, new drugs. | | Prerequisite(s): Pharmacology and Toxicology 355a/b and 358y (or the former Pharmacology and Toxicology 357) and Physiology 314a; or Pharmacology and Toxicology 355a/b and Physiology 314a and registration in Year 4 of a module in Pathology and Toxicology, or permission from the Department. | | 2 lecture hours, 0.5 course. | | back to top |
| Pharmacology and Toxicology 443a/b, Pharmacology and Toxicology of Natural-Sourced Medicine | |
| | Description: Contemporary use of medicines derived from natural sources. Regulatory aspects of their use and the scientific basis for assessment of efficacy, quality, and safety of these products will be discussed. The mechanism(s) of beneficial and harmful effects of selected natural health products, including herb-drug interactions, will be included. | | Prerequisite(s): Pharmacology and Toxicology 355a/b and 358y, or the former Pharmacology and Toxicology 357; or Pharmacology and Toxicology 355a/b and registration in Year 4 of a module in Pathology and Toxicology, or permission of the Department. | | 2 lecture hours per week, 0.5 course. | | back to top |
| Pharmacology and Toxicology 454a/b, Molecular Physiology and Pharmacology of Cell Proliferation and Tissue Repair | |
| | Description: The physiology, pathophysiology and pharmacology of cell proliferation and tissue repair. The course addresses the translation of basic molecular and cellular processes into an understanding of relevant human disorders and clinically useful therapies, through the development of appropriate in vitro and in vivo experimental models. | | Prerequisite(s): Physiology 312 or the former Physiology 310; Physiology 314a or Biology 316a; Pharmacology and Toxicology 355a/b and 358y, or the former Pharmacology and Toxicology 357, or Pharmacology and Toxicology 355a/b and registration in Year 4 of a module in Pathology and Toxicology, or permission of the Department. Biology 392a is recommended. | | 2.0 lecture hours, 0.5 course. | | back to top |
| Pharmacology and Toxicology 462a, Molecular Mechanisms of Drug Action | |
| | Description: This course is focussed on the molecular mechanisms underlying the biological effects of drugs. Content includes: i) advanced drug-receptor theory, ii) theoretical models used to predict drug effects, and iii) chemical structure-activity relationships and modern receptor structure-function analyses as they relate to drug action. | | Prerequisite(s): Pharmacology and Toxicology 355a/b and 358y, or the former Pharmacology and Toxicology 357; or Pharmacology and Toxicology 355a/b and registration in Year 4 of a module in Pathology and Toxicology, or permission of the Department. | | 2 lecture hours, 0.5 course. | | back to top |
| Pharmacology and Toxicology 463a, Principles of Toxicology | |
| | Description: Advanced studies on how chemicals produce undesirable effects in biological systems. Case study and problem-solving approaches will be used to illustrate underlying principles that govern the disposition of toxic chemical agents and dose-response relationship. Biochemical and molecular mechanisms of various forms of chemical toxicities will be examined. | | Prerequisite(s): Pharmacology and Toxicology 356a/b and 358y, or the former Pharmacology and Toxicology 357; or Pharmacology 356a/b and registration in Year 4 of a module in Pathology and Toxicology, or permission of the Department. | | 2 lecture hours, 0.5 course. | | back to top |
| Pharmacology and Toxicology 466a/b, Human Toxicology | |
| | Description: A course dealing with the pharmacological and toxicological principles underlying the adverse effects of xenobiotics in humans. In addition to reviewing mechanisms of toxicity in humans, the course will include overviews of the principles of management of human poisoning, the principles of chronic toxicity and of drug safety in humans. | | Prerequisite(s): Pharmacology and Toxicology 356a/b and 358y, or the former Pharmacology and Toxicology 357; or Pharmacology 356a/b and registration in Year 4 of a module in Pathology and Toxicology, or permission of the Department. | | 2 lecture hours, 0.5 course | | back to top |
| Pharmacology and Toxicology 480E, Experimentation and Communication in Pharmacology and Toxicology | |
| | Description: Course requirements: i) theory and practice of modern laboratory techniques, laboratory safety, appropriate use of experimental models, ii) independent research project supervised by faculty, iii) scientific communication consisting of instruction on communication skills, preparation of seminar, poster presentation and preparation of a research proposal and final research project written report. | | Prerequisite(s): Pharmacology and Toxicology 355a/b, 356a/b and 358y, or the former 357; Physiology 312 or the former 310; Physiology 314a; and registration in any of the following programs/modules: Honors Pharmacology and Toxicology, Honors Toxicology and Environmental Science, Honors Specialization in Pharmacology and Toxicology, Honors Specialization in Physiology and Pharmacology. | | Minimum 11 laboratory hours per week plus 2 seminar hours on alternate weeks, 1.5 course. | | back to top |
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