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* These courses are equivalent to pre-university introductory courses and may be counted for credit in the student's record, unless these courses were taken in a preliminary year. They may not be counted toward essay or breadth requirements, or used to meet modular admission requirements unless it is explicitly stated in the Senate-approved outline of the module.
1.0 course not designated as an essay course
0.5 course offered in first term
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0.5 course offered in first and/or second term
1.0 essay course
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0.5 essay course offered in first and/or second term
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A course that must be successfully completed prior to registration for credit in the desired course.
A course that must be taken concurrently with (or prior to registration in) the desired course.
Courses that overlap sufficiently in course content that both cannot be taken for credit.
Many courses at Western have a significant writing component. To recognize student achievement, a number of such courses have been designated as essay courses and will be identified on the student's record (E essay full course; F/G/Z essay half-course).
A first year course that is listed by a department offering a module as a requirement for admission to the module. For admission to an Honours Specialization module or Double Major modules in an Honours Bachelor degree, at least 3.0 courses will be considered principal courses.
This course consists of a series of laboratory exercises designed to familiarize the student with the basic methods in biochemistry and molecular biology, and to demonstrate concepts taught in biochemistry lecture courses. Students will learn how to present their results in an acceptable scientific format.
Students gain a deeper understanding of protein structure and folding, enzyme-mediated chemical reactions, protein regulation of networks, and methods for protein structure prediction and analysis. Students develop their ability to use computational tools to represent and analyze proteins, interpret data from primary research papers, and communicate ideas to professional audiences.
Among the topics discussed will be regulation of DNA replication, regulation of gene expression, epigenetic mechanisms of gene regulation, and application of regulatory principles in synthetic biology.
Students carry out a research project under the direction of a faculty member, gaining practical experience in a biochemistry research laboratory. Experimental design, critical thinking, and scientific communication will be emphasized, and students will develop skills at reading and reviewing primary scientific literature.
A course dealing with biochemical and molecular aspects of the human condition. Topics in human disease, medical testing, and lifestyle are considered in a clinical-case-oriented fashion. The course focuses on various aspects of cancer and structural and metabolic disorders related to carbohydrates, lipids, vitamins, minerals, nucleic acids and proteins.
The application of biochemical and molecular principles to the analytical components used to select, evaluate and interpret tests for clinical diseases. Also included will be discussions on the specialized instruments required. Students will gain understanding of the practice of clinical biochemistry, as one of the disciplines of laboratory medicine.
Students will explore the chemical and physical underpinnings of biochemical phenomena by solving practical, real-world, quantitative problems. Students will learn how to answer biochemical research questions by applying advanced experimental strategies and techniques, including methods in bioinformatics and the mining of biochemical databases.
An introduction to the principles of synthetic biology. Students learn to retrieve and apply information from databases to design and model regulated biological circuits using standard components (Biobricks). Teams of students create, communicate, and defend original synthetic biology proposals.
Introduction to synthetic biology and to philosophical questions relating to it. These include: is synthetic biology revolutionary? Can it help us gain a better understanding of life? What are the ethical dimensions of creating genetic novelty in various contexts?
The use of fundamental techniques in molecular biology and molecular genetics are illustrated using examples from the classic and current literature. Selected topics include eukaryotic gene cloning, transgenic animals, rational drug design, DNA replication and cell cycle regulation.
This course will explore how metabolic pathways are currently being re-engineered in microorganisms to produce drugs that are otherwise difficult to manufacture. We will also investigate how drug targets are being identified using newly developed chemical genetic screening methods. The impact of both approaches on medicine will be evaluated.
The course will cover applied aspects of protein chemistry in biotechnology and protein design. Topics covered will include applications of modern analytical and biophysical techniques used in proteomics and related biochemical analyses, protein structure design, and antibody engineering.
Mutation of specific human genes subverts normal cellular physiology creating characteristic alterations called ‘hallmarks’ that fuel the development of cancer. The underlying processes that alter cellular pathways and gene function will be discussed. Cancer models and molecular therapies will be related to the cancer hallmarks.
The major laboratory course for the Honours Specialization in Biochemistry and Honours Specialization modules combined with Biochemistry. Lectures on laboratory safety, biosafety, use of animals in research, scientific integrity; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).
This capstone course focuses on translation of cancer research into clinical practice, emphasizing interdisciplinary approaches, critical thinking, research design, and evaluation of literature. A community-engaged learning component connects small groups of students with relevant community partners. Students engage independently and collaboratively in authentic learning experiences and practice critical reflection.
This laboratory course is intended for students interested in pursuing graduate-level research. Lectures on literature searches, data mining, and effective communication; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (introduction to topic, mid-year report, seminar).
Prerequisite(s):Biochemistry 4483E or the former Biochemistry 4486E, and permission of the department.
Extra Information: 12 laboratory hours per week and participation in the Biochemistry Graduate Seminar.