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Academic Calendar 2009 UNDERGRADUATE COURSE INFORMATION Biochemistry (M)
INTRODUCTION
UNDERGRADUATE SESSIONAL DATES
STUDENT SERVICES
ACADEMIC INFORMATION
STUDENT FINANCIAL SERVICES
FACULTIES
UNDERGRADUATE COURSE INFORMATION
FACULTY MEMBERS
AFFILIATED UNIVERSITY COLLEGES
GLOSSARY
NEW MODULES/PROGRAMS
TABLE OF CONTENTS
Biochemistry (M)

Note:  In order to find a course in the new 4 digit numbering system using an old 3 digit number, please refer to the conversion list below. Before registering for courses with the new 4 digit numbering system, please ensure that you have not previously taken the course in its 3 digit form.

Click here for conversion list of former 3-digit course numbers.

 
2280A3380G3381A3382B3385A3386B3387G4400F
4410A4420B4430B4435A4440A4445F/G4450A4460Y
4463G4465A4480E4483E4485E4491E
Biochemistry 2280A - Biochemistry and Molecular Biology
An introduction to biochemistry with emphasis on protein structure and function, intermediary metabolism and nucleic acid structure and function.
Antirequisite(s):
Prerequisite(s): Biology 1222 or Biology 1223; Chemistry 1050 or the former Chemistry 1020 or 023; or registration in senior years of Foods and Nutrition modules.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 0.5 course.
Note: it is strongly recommended that a course in organic chemistry be taken previously or concurrently (e.g. Chemistry 2213A/B).
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Biochemistry 3380G - Biochemistry Laboratory
This course consists of a series of laboratory exercises designed to familiarize the student with the methodology of biochemistry and molecular biology.
Antirequisite(s):
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 laboratory hours, 1 tutorial hour, 0.5 course.
Enrolment limited: priority will be given to students registered in Honors Biochemistry, Biochemistry and Chemistry, or to students in Biology or Basic Medical Sciences programs, and who are taking Biochemistry 3381A and Biochemistry 3382B and have a mark of 70% or more in Biochemistry 2280A.  
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Biochemistry 3381A - Biological Macromolecules
A consideration of the structure of proteins and nucleic acids; enzymology; elements of recombinant DNA technology and related methodology.
Antirequisite(s):
Prerequisite(s): Biochemistry 2280A with a mark of at least 65%; either Chemistry 2213A/B with a minimum mark of 65% or Chemistry 2273A with a minimum mark of 60%; either Chemistry 2223B with a minimum mark of 65% or Chemistry 2283G with a minimum mark of 60%.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 1 tutorial hour, 0.5 course.
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Biochemistry 3382B - Biochemical Regulation
Among the topics discussed will be principles of metabolic control, membrane signal transduction and mechanisms of hormonal control of metabolism, growth and differentiation.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 1 tutorial hour, 0.5 course.
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Biochemistry 3385A - Human Biochemistry
A course dealing with Biochemical aspects of the human condition. Topics in human disease, medical testing, and lifestyle will be considered in a clinical-case-oriented fashion. The emphasis will be on structural and metabolic issues related to carbohydrates, lipids, vitamins, minerals, nucleic acids and proteins.
Antirequisite(s):
Prerequisite(s): Biochemistry 2280A with a mark of at least 75%.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 0.5 course.
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Biochemistry 3386B - Clinical Biochemistry
The application of biochemical and molecular principles to the analytical components used to select, evaluate and interpret tests for clinical diseases. Also included will be discussions on the specialized instruments required. Students will gain understanding of the practice of clinical biochemistry, as one of the disciplines of laboratory medicine.
Antirequisite(s):
Prerequisite(s): Biochemistry 2280A with a mark of at least 70%.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 0.5 course.
Enrolment limited.
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Biochemistry 3387G - Clinical Biochemistry Laboratory
This course is designed to introduce students to the methods and technologies relevant to the use of biochemistry in the diagnosis of human disease. The course will consist of laboratory exercises designed to gain experience in laboratory techniques, tutorials and rotations through selected clinical labs, and lab exercises in molecular diagnostics.
Antirequisite(s):
Prerequisite(s): Biochemistry 2280A with a mark of at least 70%; Chemistry 2213A/B and 2223B with an average of at least 65%, or Chemistry 2273A and 2283G with a minimum mark of 60% in each.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 laboratory hours per week, 1 tutorial hour, 0.5 course.
Enrolment limited: Priority will be given to students enrolled in the Honors Specialization in Clinical Biochemistry with highest academic standing in the prerequisite courses.
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Biochemistry 4400F - Membrane Biochemistry
An advanced treatment of structure, transport, energetics, and biogenesis of membranes.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4410A - Molecular Biology of DNA and RNA
The use of fundamental techniques in molecular biology and molecular genetics are illustrated using examples from the classic and current literature. Selected topics include eukaryotic gene cloning, transgenic animals, rational drug design, DNA replication and cell cycle regulation.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A and 3382B.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4420B - Molecular Biology of Proteins
Topics to be considered at an advanced level will include: translation, folding and assembly, targeting, turnover, structure and motifs.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4430B - Molecular Biology of Signal Transduction
A discussion of the molecular mechanisms involved in the responses of cells to extracellular stimuli (i.e., growth factors). The molecular mechanisms involved in responses of cells to the nucleus, changes in gene expression, and subsequent changes in cellular events; both in normal conditions and in disease.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A and Biochemistry 3382B.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4435A - Field Guide to the Human Genome.
An introduction to the analysis of human genomic sequences using internet-based bioinformatic resources. The goal is to provide the student with the understanding needed to address questions about genome architecture, coding and non-coding genes, gene products, and genetic regulation.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A and Biology 2581B.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: Recommended: Biochemistry 3382B.
2 lecture/demonstration hours; 2 laboratory hours every other week, 0.5 course.
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Biochemistry 4440A - Protein Structure, Analysis and Design
This course will provide the necessary methodology and technology to study protein structure, interactions, characterization and design of novel functional proteins. Techniques and applications broadly applicable to biology will be discussed including the theory and application of optical and NMR spectroscopies, X-ray crystallography, ultracentrifugation and mass spectroscopy.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4445F/G - Macromolecular Informatics
The course will provide a project oriented approach to teach students how to access appropriate genomic and protein data bases, what search methods to use, how to interpret results and how to integrate information to address particular biological questions.
Antirequisite(s):
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 3 laboratory hours, 0.5 course.
Enrolment limited.
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Biochemistry 4450A - Molecular Genetics of Human Cancer
Key cellular pathways that are frequently subverted in tumour cells leading to neoplasia will be discussed, as well as mechanisms by which environmental factors affect tumour development. Cancer models and molecular therapies will also be considered.
Antirequisite(s):
Prerequisite(s): Biology 2581B, Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4460Y - Bioinformatics Research Project
The major research project course for students in Honors Bioinformatics. The course consists of: an independent research project (topic and supervisor chosen by consultation between student and faculty); lectures on scientific integrity; scientific communication (two seminars and a written report).
Antirequisite(s): Computer Science 4460Z, Biochemistry 4483E, 4491E, and the former Biochemistry 484E.
Prerequisite(s): Registration in year 4 of an Honors Specialization in Bioinformatics (Biochemistry concentration).
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 10 hours, 0.5 course.
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Biochemistry 4463G - Biochemistry of Genetic Diseases
In this course, knowledge of molecular biology and biochemistry is applied to the understanding of human genetic diseases. Topics of current interest are used as examples to study the transition from mutations to clinical disorders. Societal and ethical issues are discussed.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4465A - Instrumentation for Proteomics and Related Analyses
The principles and applications of modern analytical techniques used in proteomics and related biochemical analyses will be introduced. These techniques include chromatography, electrophoresis, mass spectrometry, differential scanning calorimetry, surface plasmon resonance and surface imaging microscopy.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4480E - Biochemistry and Cell Biology Research Project and Seminar
The course consists of: lectures on laboratory safety, biosafety, use of animals in research, scientific integrity; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication.
Antirequisite(s): Anatomy and Cell Biology 4480E, Biochemistry 4483E, 4485E, 4491E, Microbiology and Immunology 4970E, the former Biochemistry 484E, the former Microbiology and Immunology 484.
Prerequisite(s): Biochemistry 3380G, 3381A, 3382B with marks in each of at least 70%. Enrolment is limited, and is available only to students in the final year of an Honors Specialization in Biochemistry and Cell Biology.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 15 hours per week, 1.5 courses.
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Biochemistry 4483E - Research Project and Seminar
The major laboratory course for students in Honors Specialization Biochemistry. The course consists of: lectures on laboratory safety, biosafety, use of animals in research, scientific integrity; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).
Antirequisite(s): Biochemistry 4491E, Medical Sciences 4400E, 4490F/G, Microbiology and Immunology 4970E, the former Biochemistry 484E, the former Microbiology and Immunology 484.
Prerequisite(s): Biochemistry 3380G, 3381A and 3382B, with marks in each of at least 70%. Enrolment is limited, and is available only to students in Year 4 of an Honors Specialization in either Biochemistry or Biochemistry of Infection and Immunity. Students in the Honors Specialization in Biochemistry of Infection and Immunity may substitute Microbiology and Immunology 3600G with a minimum mark of 70% for Biochemistry 3380G as a prerequisite.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 15 hours per week, 1.5 course.
Enrolment in this course is limited.
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Biochemistry 4485E - Clinical Biochemistry Research Project Seminar
This is the major laboratory course intended for students in the Honors Specialization in Clinical Biochemistry. The course consists of lectures on laboratory safety and scientific integrity; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars/written report).
Antirequisite(s): Biochemistry 4483E, 4491E, Microbiology and Immunology 4970E, the former Biochemistry 484E, the former Microbiology and Immunology 484.
Prerequisite(s): Biochemistry 3381A, 3382B and 3387G, with marks in each of at least 70%. Priority will be given to students in the Honors Specialization in Clinical Biochemistry.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 15 hours per week, 1.5 course.
Enrolment limited.
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Biochemistry 4491E - Research Project and Seminar
The major laboratory course for students in Honors Specialization Biochemistry and Chemistry. The course consists of: lectures on laboratory safety, biosafety, use of animals in research, scientific integrity; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).
Antirequisite(s): Biochemistry 4483E, Chemistry 4490E, Medical Sciences 4400E, 4490F/G, Microbiology and Immunology 4970E, the former Biochemistry 484E, the former Microbiology and Immunology 484.
Prerequisite(s): Biochemistry 3380G, 3381A, 3382B, with marks in each of at least 70%. Enrolment is limited, and is available only to students in Year 4 of an Honors Specialization in Biochemistry and Chemistry.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 12 hours per week, 1.0 course.
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Academic Calendar 2009 UNDERGRADUATE COURSE INFORMATION Biochemistry (M)
Decision Academic