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Academic Calendar 2017 UNDERGRADUATE COURSE INFORMATION Biochemistry (M)
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TABLE OF CONTENTS




Biochemistry (M)
Biochemistry 2280A - Biochemistry and Molecular Biology
An introduction to biochemistry with emphasis on protein structure and function, intermediary metabolism and nucleic acid structure and function.
Antirequisite(s): Biochemistry 2288A.
Prerequisite(s): Either Biology 1001A or 1201A and either Biology 1002B or 1202B; Chemistry 1301A/B and 1302A/B, or the former Chemistry 1100A/B and 1200B. Integrated Science 1001X can be used as a prerequisite in place of Biology 1002B and Chemistry 1302A/B.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 0.5 course.
Note: It is strongly recommended that a course in organic chemistry be taken previously or concurrently (e.g. Chemistry 2213A/B or 2273A).
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Biochemistry 2288A - Biochemistry and Molecular Biology for Foods and Nutrition
An introduction to biochemistry with emphasis on protein structure and function, intermediary metabolism and nucleic acid structure and function.
Antirequisite(s): Biochemistry 2280A.
Prerequisite(s): Chemistry 1301A/B and 1302A/B, or the former Chemistry 1100A/B and 1200B or 1050; Biology 1290B; and registration in senior years of Foods and Nutrition modules.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 0.5 course.
Note: It is strongly recommended that a course in organic chemistry be taken previously or concurrently (e.g. Chemistry 2213A/B or 2273A).
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Biochemistry 3380G - Biochemistry Laboratory
This course consists of a series of laboratory exercises designed to familiarize the student with the basic methods in biochemistry and molecular biology, and to demonstrate concepts taught in biochemistry lecture courses. Students will learn how to present their results in an acceptable scientific format.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A and 3382A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 laboratory hours, 1 tutorial hour, 0.5 course.
Enrolment limited: priority will be given to students who have achieved a mark of at least 70% in Biochemistry 2280A and are registered in modules offered by the Department of Biochemistry, other Basic Medical Science departments, or the Department of Biology.
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Biochemistry 3381A - Biological Macromolecules
A consideration of the structure of proteins and nucleic acids; enzymology; elements of recombinant DNA technology and related methodology.
Antirequisite(s):
Prerequisite(s): A minimum mark of 65% in either Biochemistry 2280A or 2288A; a minimum mark of 60% in either Chemistry 2213A/B or 2273A; and a minimum mark of 60% in either Chemistry 2223B or 2283G.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 1 tutorial hour, 0.5 course.
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Biochemistry 3382A - Biochemical Regulation
Among the topics discussed will be principles of metabolic control, mechanisms of signal transduction, regulation of DNA replication, regulation of gene expression, and epigenetic mechanisms of gene regulation.
Antirequisite(s):
Prerequisite(s): A minimum mark of 65% in either Biochemistry 2280A or 2288A; a minimum mark of 60% in either Chemistry 2213A/B or 2273A; and a minimum mark of 60% in either Chemistry 2223B or 2283G.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 1 tutorial hour, 0.5 course.
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Biochemistry 3383F/G - Introduction to Biochemical Research
Students carry out a research project under the direction of a faculty member, gaining practical experience in a biochemistry research laboratory.á Experimental design, critical thinking, and scientific communication will be emphasized, and students will develop skills at reading and reviewing primary scientific literature.
Antirequisite(s):
Prerequisite(s): Permission of the Department.
Corequisite(s):
Pre-or Corequisite(s): Biochemistry 3381A and 3382A.
Extra Information: 5 laboratory hours per week, 0.5 course.
Enrolment in this course is limited.
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Biochemistry 3385A - Human Biochemistry
A course dealing with Biochemical aspects of the human condition. Topics in human disease, medical testing, and lifestyle will be considered in a clinical-case-oriented fashion. The emphasis will be on structural and metabolic issues related to carbohydrates, lipids, vitamins, minerals, nucleic acids and proteins.
Antirequisite(s):
Prerequisite(s): A minimum mark of 70% in either Biochemistry 2280A or 2288A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 0.5 course.
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Biochemistry 3386B - Clinical Biochemistry
The application of biochemical and molecular principles to the analytical components used to select, evaluate and interpret tests for clinical diseases. Also included will be discussions on the specialized instruments required. Students will gain understanding of the practice of clinical biochemistry, as one of the disciplines of laboratory medicine.
Antirequisite(s):
Prerequisite(s): Either Biochemistry 2280A or 2288A with a mark of at least 70%.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture hours, 0.5 course.
Enrolment limited.    
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Biochemistry 3390B - Advanced Methods for Biochemistry
Students will explore the chemical and physical underpinnings of biochemical phenomena by solving practical, real-world, quantitative problems. Students will learn how to answer biochemical research questions by applying advanced experimental strategies and techniques, including methods in bioinformatics and the mining of biochemical databases.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A and 3382A
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 1 tutorial hour, 0.5 course.
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Biochemistry 4410A - Molecular Biology of DNA and RNA
The use of fundamental techniques in molecular biology and molecular genetics are illustrated using examples from the classic and current literature. Selected topics include eukaryotic gene cloning, transgenic animals, rational drug design, DNA replication and cell cycle regulation.
Antirequisite(s):
Prerequisite(s): Biochemistry 3381A and 3382A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4415B - Applications of Synthetic Biology and Chemical Genetics in Medicine
This course will explore how metabolic pathways are currently being re-engineered in microorganisms to produce drugs that are otherwise difficult to manufacture. We will also investigate how drug targets are being identified using newly developed chemical genetic screening methods. The impact of both approaches on medicine will be evaluated.
Antirequisite(s):
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours per week, 1 hr bi-weekly tutorial   session, 0.5 course.
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Biochemistry 4420A - Molecular Biology of Proteins
Topics to be considered at an advanced level will include: translation, folding and assembly, targeting, turnover, structure and motifs.
Antirequisite(s): The former Biochemistry 4420B.
Prerequisite(s): Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4425B - Proteomics and Protein Biotechnology
The course will cover applied aspects of protein chemistry in biotechnology and protein design. Topics covered will include applications of modern analytical and biophysical techniques used in proteomics and related biochemical analyses, protein structure design, and antibody engineering.

Antirequisite(s):
Prerequisite(s): Biochemistry 4420A
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours per week, 0.5 course.
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Biochemistry 4450A - Molecular Genetics of Human Cancer
Key cellular pathways that are frequently subverted in tumour cells leading to neoplasia will be discussed, as well as mechanisms by which environmental factors affect tumour development. Cancer models and molecular therapies will also be considered.
Antirequisite(s):
Prerequisite(s): Biology 2581B, Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4455G - Translational Concepts in Cancer Biology
The translation of cancer research discoveries into clinical practice, emphasizing critical thinking, research design, evaluation of data from the literature and ethics. Students will engage with community partners associated with cancer research, patient support and care, and will work on a team project relevant to the partnersĺ needs.
Antirequisite(s):
Prerequisite(s): Biochemistry 4450A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 3 lecture/tutorial hours per week; 0.5 course.
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Biochemistry 4463B - Biochemistry of Genetic Diseases
In this course, knowledge of molecular biology, biochemistry, cytogenetics, and genomics is applied to the understanding of human genetic diseases. Topics of current interest are used as examples to study the transition from mutations to clinical disorders.
Antirequisite(s): Biology 4560A/B.
Prerequisite(s): Biochemistry 3381A.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 2 lecture hours, 0.5 course.
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Biochemistry 4483E - Research Project and Seminar
The major laboratory course for the Honors Specialization in Biochemistry andáHonors Specialization modulesácombined with Biochemistry. Lectures on laboratory safety, biosafety, use of animals in research, scientific integrity; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).
Prerequisite(s): Biochemistry 3380G, 3381A and 3382A, with marks in each of at least 70%. Enrolment is limited, and is available only to students in Year 4 of Honors Specialization modules in Biochemistry, Biochemistry and Cell Biology, Biochemistry and Pathology of Human Disease, Biochemistry and Chemistry, Biochemistry of Infection and Immunity, Computational Biochemistry, and Medical Biophysics and Biochemistry. Students in the Honors Specialization in Biochemistry of Infection and Immunity may substitute one of Microbiology and Immunology 3610F, 3620G, or the former 3600G with a minimum mark of 70% in lieu of Biochemistry 3380G as a prerequisite. Students in the Honors Specialization in Computational Biochemistry may substitute Biochemistry 3383F/G with a minimum mark of 70% in lieu of Biochemistry 3380G as a prerequisite.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 15 hours per week, 1.5 course.
Enrolment in this course is limited.
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Biochemistry 4486E - Cancer Biology Research Project and Seminar
The major laboratory course for the Honors Specialization in Biochemistry and Cancer Biology. Lectures on safety, use of animals in research, scientific integrity; an independent cancer-related research project (topic and advisor chosen by consultation between student and faculty); scientific communication (two seminars and a written report).
Prerequisite(s): A mark of at least 70% in one of the following: Biochemistry 3380G, Microbiology and Immunology 3620G, or the former Pharmacology 3580Z; and enrolment in Year 4 of the Honors Specialization in Biochemistry and Cancer Biology.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 15 hours per week, indicate lecture/tutorial/lab hours, 1.5 course.
To be offered for the first time in 2018/19.
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Biochemistry 4999E - Advanced Research in Biochemistry
This laboratory course is intended for students interested in pursuing graduate-level research. Lectures on literature searches, data mining, and effective communication; an independent research project (topic and advisor chosen by consultation between student and faculty); scientific communication (introduction to topic, mid-year report, seminar).
Antirequisite(s):
Prerequisite(s): Biochemistry 4483E or the former 4485E, and permission of the department.
Corequisite(s):
Pre-or Corequisite(s):
Extra Information: 12 laboratory hours per week and participation in the Biochemistry Graduate Seminar, 1.0 course.
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Academic Calendar 2017 UNDERGRADUATE COURSE INFORMATION Biochemistry (M)
Decision Academic